Dr Sheila Singh

McMaster University

Dr Sheila Singh
Dr Sheila Singh discovered a new way to kill brain cancer cells with an old drug.

Dr Sheila Singh and her team studied a protein called CD133 that is highly expressed on certain glioblastoma (GBM) cells. These cells in this aggressive brain cancer act like stem cells by initiating and sustaining tumour growth and resisting treatment. The researchers identified pyrvinium, a drug originally approved to treat pinworm infections, as a promising lead to selectively trigger death of CD133-marked GBM cells.

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Reference: Clinical Cancer Research, December 2015