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Risk factors for nasopharyngeal cancer
A risk factor is something that increases the risk of developing cancer. It could be a behaviour, substance or condition. Most cancers are the result of many risk factors. The most important risk factor for developing nasopharyngeal cancer is Southeast Asian or Chinese ancestry, particularly Cantonese ancestry.
Nasopharyngeal cancer is more common in men than women. The risk for this cancer increases with age. The highest rate of nasopharyngeal cancer is in people older than 50 years of age. Having a low socio-economic status is also linked with a higher risk.
Risk factors are generally listed in order from most to least important. But in most cases, it is impossible to rank them with absolute certainty.
There is convincing evidence that the following factors increase your risk for nasopharyngeal cancer.
The highest rates of nasopharyngeal cancer in the world are in Hong Kong, southern China and Southeast Asia. In North America, nasopharyngeal cancer rates are highest among the Inuit.
People of Southeast Asian and Chinese ancestry, particularly Cantonese ancestry, have high rates of nasopharyngeal cancer. Rates of this cancer are also high in second-generation people with these ancestries who have moved to areas where the rate of nasopharyngeal cancer is low.
Nasopharyngeal cancer is rare in Caucasians. The rate of this cancer is higher in Caucasians born in areas where the rate is high, such as in China.
Salt-cure fish and meats are made by coating them with dry salt or by putting them in a salt solution. A diet high in salt-cured fish, meat or both is common in Southeast Asia, Southern China and northern Africa. It is also common among Inuit people in the Alaskan and Canadian Arctic.
Rates of nasopharyngeal cancer are high in areas where eating salt-cured foods, especially Chinese-style salted fish, is very common. People who were fed salt-cured fish when they were children, especially when they were weaning, also have a higher risk of developing nasopharyngeal cancer.
Epstein-Barr virus (EBV) is a type of herpes virus that causes infectious mononucleosis (a very contagious disease that causes fever, fatigue, malaise and sore throat). Infection with EBV usually occurs in childhood. Most people develop only mild or no symptoms. Many people diagnosed with nasopharyngeal cancer have a high level of antibodies to EBV in their blood.
Although many people with nasopharyngeal cancer have an EBV infection, not all people with an EBV infection develop nasopharyngeal cancer. EBV may cause nasopharyngeal cancer in people who also have other risk factors, such as ancestry or diet.
Find out more about Epstein-Barr virus (EBV).
Smoking tobacco increases your risk of nasopharyngeal cancer. The risk increases with the amount and length of time you smoke.
Breathing in formaldehyde at work increases the risk of nasopharyngeal cancer. The longer you come into contact with formaldehyde, the greater your risk for developing the disease.
Breathing in wood dust at work increases the risk of nasopharyngeal cancer. The longer you come into contact with wood dust, the greater your risk.
Possible risk factors
A diet low in vegetables and fruit is a possible risk factor for nasopharyngeal cancer. This means that it has been linked with nasopharyngeal cancer, but there is not enough evidence to show for sure that it is a risk factor.
Questions to ask your healthcare team
To make the decisions that are right for you, ask your healthcare team questions about risks.
I’m extremely grateful to the Canadian Cancer Society for funding my research with an Innovation Grant.
How can you stop cancer before it starts?
Discover how 16 factors affect your cancer risk and how you can take action with our interactive tool – It’s My Life! Presented in partnership with Desjardins.