Dr Trang Hoang is targeting resistant cells in childhood leukemia.
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Dr Trang Hoang and her team found that abnormal pre-ALL stem cells are 10 to 20 times more resistant to chemotherapy than other leukemic cells, which could explain why the cancer comes back in some children despite treatment. They also identified a promising chemical that could wipe out these stem cells.
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Reference: Journal of Clinical Investigation, October 2016