What is uterine cancer?

Last medical review:

Uterine cancer is the most common cancer of the female reproductive system in Canada. Uterine cancer starts in the cells of the uterus. A cancerous (malignant) tumour is a group of cancer cells that can grow into nearby tissue and destroy it. The tumour can also spread (metastasize) to other parts of the body.

The uterus is part of the female reproductive system. The uterus is the hollow, muscular, pear-shaped organ where a fetus develops and grows during pregnancy. The inner lining of the uterus is called the endometrium. It is made up of tissue with many glands. The lower part of the uterus is called the cervix. The cervix leads into the vagina.

Diagram of the female reproductive system
Diagram of the female reproductive system

Cells in the uterus sometimes change and no longer grow or behave normally. These changes can lead to non-cancerous (benign) conditions such as endometriosis. They can also lead to non-cancerous tumours such as uterine fibroids.

Changes to the cells of the uterus can also cause precancerous conditions. This means that the abnormal cells are not yet cancer, but there is a chance that they will become cancer if they aren’t treated. The precancerous condition of the uterus is called endometrial hyperplasia.

But in some cases, changes to cells of the uterus can cause uterine cancer. Most often, uterine cancer starts in the gland cells of the endometrium. This type of cancer is called endometrial carcinoma. A less common type of uterine cancer is uterine sarcoma. It starts in the muscle cells of the uterus.

Expert review and references

  • Alektiar KM, Abu-Rustum NR, Makker V, et al. Cancer of the uterine body. Devita VT, Lawrence TS, Rosenberg SA, eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, chapter 50, https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • Canadian Cancer Society. Canadian Cancer Statistics 2024. 2024. https://cancer.ca/en/research/cancer-statistics.
  • Hacker NF, Friedlander ML. Uterine cancer. Berek J, Hacker NF. Berek and Hacker's Gynecologic Oncology. 7th ed. Philadelphia, PA: Wolters Kluwer; 2021: 10:371–420.
  • Martini FH, Tallitsch RB, Nath JL. Human Anatomy. 9th ed. New York, NY: Pearson; 2018.
  • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Uterine Neoplasms (Version 3.2024). 2024.
  • PDQ Adult Treatment Editorial Board. Endometrial Cancer Treatment (PDQ®)–Health Professional Version. National Cancer Institute; 2024. https://www.cancer.gov/.

The uterus

The uterus is the part of the female reproductive system where a baby can grow and develop.

Endometrial carcinoma

Endometrial carcinoma is the most common type of uterine cancer. It is divided into different subtypes.

Uterine sarcoma

Uterine sarcoma is a rare type of uterine cancer.

Endometrial intraepithelial neoplasia (EIN)

Endometrial intraepithelial neoplasia (EIN) is a precancerous condition of the uterus. It's treated with surgery or hormone therapy.

Uterine fibroids

Uterine fibroids are a common non-cancerous tumour of the uterus.

Endometriosis

Endometriosis is a common non-cancerous condition of the uterus.

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