Risks for salivary gland cancer

Last medical review:

Some things can affect your risk, or chance, of developing cancer. Certain behaviours, substances or conditions can increase or decrease the risk. Most cancers are the result of many risks. But sometimes cancer develops in people who don’t have any risks.

Salivary gland cancer can occur at almost any age, but the risk increases as people get older. It occurs most often in people older than 50.

Exposure to radiation increases your risk for salivary gland cancer. In most cases, this risk can’t be changed because it comes from past exposure. Until we learn more, there are no specific ways to lower your risk for salivary gland cancer.

Exposure to radiation

Ionizing radiation is a known risk for cancer. The risk is related to how much radiation someone is exposed to.

People who have had radiation therapy to the head or neck and people who were exposed to ionizing radiation during atomic bomb explosions have a higher risk for salivary gland cancer.

People who have had many full-mouth dental x-rays also have a higher risk for salivary gland cancer. This is especially true for people who had these x-rays before the 1960s when the doses of radiation were much higher.

Possible risks

The following have been linked with an increased risk of salivary gland cancer, but more research is needed to know for sure that they are risks:

  • treatment with iodine 131 (I-131), a type of radioactive iodine, for thyroid cancer
  • Epstein-Barr virus (EBV) infection
  • human immunodeficiency virus (HIV) infection
  • smoking tobacco

Understanding your cancer risk

To make the decisions that are right for you, ask your doctor questions about risks. Learn how cancer can be prevented and what you can do to reduce your risk.

Expert review and references

  • Canadian Cancer Society | Société canadienne du cancer
  • Chera BS, Zevallos J, Hanna GJ. Cancer of the salivary gland. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, chapter 29, https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • Hashibe M, Sturgis EM, Ferlay J, & Winn DM. Oral cavity, oropharynx, lip and salivary glands. Thun MJ (ed.). Schottenfeld and Fraumeni Cancer Epidemiology and Prevention. 4th ed. New York, NY: Oxford University Press; 2018: 29: 543-577.
  • International Agency for Research on Cancer (IARC). IARC Monographs on the Idenification of Carcinogenic Hazards to Humans Volume 100D: Radiation: A Review of Human Carcinogens. 2011.
  • International Agency for Research on Cancer (IARC). IARC Monographs on the Idenification of Carcinogenic Hazards to Humans Volume 100E: Personal Habits and Indoor Combustions. 2012.
  • Young A, Okuyemi OT. Malignant salivary gland tumors. StatPearls [Internet]. StatPearls Publishing; 2023. https://www.statpearls.com/.

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