Prostate cancer

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Prostatic intraepithelial neoplasia (PIN), atypical small acinar proliferation (ASAP) and proliferative inflammatory atrophy (PIA) are conditions of the prostate. They are usually found when doctors remove tissue from the prostate to diagnose or treat a different problem, such as benign prostatic hyperplasia (BPH). Some experts classify PIN, ASAP and PIA as precancerous conditions, but most experts don’t think they are linked to a higher chance of developing prostate cancer. So men with PIN, ASAP and PIA aren’t treated, and only men who have ASAP need follow-up.

Prostatic intraepithelial neoplasia (PIN)

PIN is an abnormal condition of the epithelial cellsepithelial cellsA specialized cell that makes up the epithelium (a layer of cells that lines the body’s hollow organs and glands and makes up the outer layer of the skin). Some epithelial cells produce mucus or other secretions. that line the glands of the prostate. It can affect more than one area of the prostate (called multifocal PIN). PIN is usually found by a biopsybiopsyThe removal of cells or tissues for examination under a microscope. to check for prostate cancer or during a transurethral resection of the prostate (TURP), a type of surgery used to treat BPH.

Atypical small acinar proliferation (ASAP)

ASAP is an abnormal growth of gland cells in the prostate. Some men with ASAP may have prostate cancer, so some doctors recommend doing a follow-up biopsy in 6 months. If the repeat biopsy also shows ASAP, doctors may recommend treatment.

Proliferative inflammatory atrophy (PIA)

PIA means there are areas of inflammation in the prostate and the prostate cells look smaller than normal.


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