Grades of penile cancer
Grading is a way of classifying penile cancer cells based on their appearance and behaviour when viewed under a microscope. To find out the grade of a tumour, the biopsy sample is examined under a microscope. A grade is given based on how the cancer cells look and behave compared with normal cells (differentiation). This can give the healthcare team an idea of how quickly the cancer may be growing and how likely it is to spread.
The grade of penile cancer is based on the degree of differentiation of cells and their rate of growth.
grade of differentiation cannot be assessed
well differentiated or low grade – slow growing, less likely to spread
moderately well differentiated or moderate grade
poorly differentiated or high grade – tend to grow quickly, more likely to spread
undifferentiated or high grade – tend to grow very quickly, likely to spread
Grading plays an important part in planning penile cancer treatment and can also be used to help estimate the prognosis (future outcome).