Childhood non-Hodgkin lymphoma

You are here: 

Treatments for primary mediastinal B-cell lymphoma

The following are treatment options for primary mediastinal B-cell lymphoma. The healthcare team will suggest treatments based on your child’s needs and work with you to develop a treatment plan. Treatments are often based on the stage or risk group.

Chemotherapy

Chemotherapy is the main treatment for primary mediastinal B-cell lymphoma. Chemotherapy often includes targeted therapy drugs.

Chemotherapy drugs are given in different combinations based on different treatment plans (called protocols). The most common chemotherapy combination used is:

  • etoposide (Vepesid, VP-16)
  • doxorubicin (Adriamycin)
  • cyclophosphamide (Cytoxan, Procytox)
  • vincristine (Oncovin)
  • prednisone
  • rituximab (Rituxan)

Intrathecal chemotherapy may be given to prevent spread of NHL to the brain and spinal cord (called the central nervous system, or CNS) or to treat NHL that has spread to the CNS. This means that the drugs are given directly into the cerebrospinal fluid (CSF) around the brain and spinal cord. Intrathecal chemotherapy can include 1 to 3 of the following drugs:

  • methotrexate
  • cytarabine
  • prednisolone
  • hydrocortisone

Targeted therapy

Targeted therapy with rituximab may be used to treat children with primary mediastinal B-cell lymphoma, in combination with chemotherapy, in a clinical trial setting.

Clinical trials

Many children with childhood primary mediastinal B-cell lymphoma will be treated in a clinical trial that is tailored to the risk group or stage of their disease. The clinical trial protocol, or plan, outlines the treatments used (such as chemotherapy or targeted therapy), as well as the drugs and dosages used. Find out more about clinical trials.

Stories

Dr Daniel De Carvalho Tricking cancer stem cells to stop growing

Read more

What’s the lifetime risk of getting cancer?

Icon - 1 in 2

The latest Canadian Cancer Statistics report shows about half of Canadians are expected to be diagnosed with cancer in their lifetime.

Learn more